Biochem/physiol Actions

Nuclear receptor subfamily 4 group A member 1 (NR4A1) is essential for regulation of cell proliferation, apoptosis and energy metabolism. Nur77 is an acetylated protein, modulated by histone acetyltransferase p300 (p300) and histone deacetylase 1 (HDAC1) for its rapid turnover. Nur77 regulates liver kinase B1 (LKB1)- AMP (adenosine monophosphate)-activated protein kinase (AMPK) and plays a major role in glucose metabolism. Expression of Nur77 in skeletal muscle promotes glucose uptake by enhancing insulin pathway and upregulates glycolysis pathway. Expression of Nur77 in hepatocytes promotes gluconeogenesis. Mutation in Nur77 may result in diet-induced obesity and insulin resistance in tissues. Nur77 is a potential drug target for metabolic disorders. NR4A1 is an anti-oncogenic protein that reduces the tumour cell proliferation and metastasis. NR4A1 increases the gastric cancer cells sensitivity towards tumour necrosis factor α (TNF-α) mediated apoptotic pathway. NR4A1 is downregulated in breast cancer, leukemia. NR4A1 plays a crucial role and a potent therapeutic target for fibrosis of endometriosis.

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General description

Nuclear receptor subfamily 4 group A member 1 (NR4A1) also known as nuclear hormone receptor 77 (NUR77), belongs to NR4A subfamily nuclear hormone receptors. In human chromosome, the gene NR4A1 is localized on 12q13.13.

Immunogen

Peptide sequence around phosphorylation site of Serine351(L-P-S(p)-K-P) derived from Human Nuclear Receptor NR4A1.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Specificity

The antibody detects endogenous levels of Nuclear Receptor NR4A1 only when phosphorylated at serine 351